Jublia (Efinaconazole) - Topical


What Is Jublia?

Jublia (efinaconazole) is an antifungal drug used to treat onychomycosis (fungal infections of the toenails). It belongs to a drug class called azole antifungals.

Jublia is a clear and colorless to pale yellow topical liquid. It works by stopping the growth of specific types of fungus that can cause toenail infection. Hence, causing the death of the fungus.

Drug Facts

Generic Name: Efinaconazole

Brand Name(s): Jublia

Drug Availability: Prescription

Therapeutic Classification: Antifungal

Available Generically: Yes

Controlled Substance: N/A

Administration Route: Topical

Active Ingredient: Efinaconazole

Dosage Form(s): Solution 

What Is Jublia Used For?

Jublia (efinaconazole) is a 10% topical solution used to treat onychomycosis (fungal infections of the toenails). It's unknown if Jublia is safe to use in children. However, studies show older adults may tolerate its use.

Jubilia (Efinaconazole) Drug Information - Illustration by Zoe Hansen

Verywell / Zoe Hansen

How to Use Jublia 

  1. Clean and dry the affected toenail(s).
  2. After bathing or showering, wait at least 10 minutes before applying this drug.
  3. Apply Jublia to affected toenails once daily for 48 weeks.
  4. Gently apply the solution using the applicator brush all over the toenail-folds, toenail bed, skin under your nail, and undersurface of your toenail plate-and allow the solution to dry thoroughly.
  5. After each use, wash your hands with water and soap.

Do not take Jublia by mouth, put it in your eyes, or apply it vaginally. 

Jublia may catch fire. Do not apply it near a flame, fire, or heat source while smoking. 

Avoid pedicures, nail polish or cosmetic nail products while using Jublia. 


Store Jublia at room temperature (68 to 77 degrees F) in a dry place. Do not store it in your bathroom. You may store between cool and slightly warm temperatures (59 to 86 degrees F). Keep away from heat or flame. Do not freeze.

Stand the bottle upright and keep it tightly closed when not in use.

Keep Jublia away from children and pets.

Throw away unused or expired drugs. Do not toss down the sink, drain, or toilet. Ask your pharmacist about medication take-back programs in your area and the best ways to dispose of your unused medicine.

How Long Does Jublia Take to Work?

You may have to use Jublia for at least 48 weeks to see its full effects.

What Are the Side Effects of Jublia?

This is not a complete list of side effects and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your pharmacist or a healthcare provider. You may report side effects to the Food and Drug Administration (FDA) at fda.gov/medwatch or 1-800-FDA-1088.

Common Side Effects

Common side effects of Jublia (efinaconazole) include:

  • Dermatitis (dry, itchy, irritated skin)
  • Irritation in one area of your body
  • Continued pain or irritation in one area of your body

Severe Side Effects

Jublia may cause severe side effects. Tell your healthcare provider right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you are having a medical emergency. Severe side effects include:

  • Ingrown toenail
  • Severe irritation at the medication application site
  • Signs of an allergic reaction like hives

Report Side Effects

Jublia may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your healthcare provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Jublia Should I Use?

Drug Content Provided and Reviewed by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (solution):
    • For treatment of fungal infection of the toenails:
      • Adults and children 6 years of age and older—Apply to the affected toenail(s) once a day for 48 weeks.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.


Treatment with Jublia may need to be modified or monitored more closely in certain populations and under specific circumstances.

Pregnancy: High-quality research studying Jublia (efinaconazole) in pregnant people is lacking. This drug may only be used during pregnancy if the possible benefits outweigh the risks to the fetus.

Nursing: It is unknown if this drug may be present in breast milk. However, once applied to your skin, your body may absorb small amounts of Jublia. If you're breastfeeding, talk to your healthcare provider before using this medicine.

Children: The safety and usefulness of Jublia in children have not been established.

Adults over the age of 65 years: Jublia may be well tolerated by older adults, including beyond 12 months of use.

Missed Dose

Apply the missed dose once you think of it. If it's too close to your next application time, skip the missed dose. Do not apply two doses or extra amounts.

Overdose: What Happens If I Use Too Much Jublia?

If you apply too much of this medicine, wash it off.

Call your healthcare provider or the Poison Control Center right away if you think you or someone else may have ingested or overdosed on Jublia. 

What Happens If I Overdose on Jublia?

If you think you or someone else may have overdosed on Jublia, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Jublia, call 911 immediately.


Drug Content Provided and Reviewed by IBM Micromedex®

It is very important that your doctor check your or your child's progress at regular visits. This will allow your doctor to see if the medicine is working properly and check you for any problems or unwanted effects that may be caused by this medicine.

If your toenail problem does not improve or if it becomes worse, check with your doctor.

Check with your doctor right away if you have itching, swelling, redness, or irritation at the application site.

What Are Reasons I Shouldn't Use Jublia?

Avoid taking Jublia if you are allergic to it or any of its ingredients.

What Other Medications Interact With Jublia?

Interactions for Jublia are lacking. Talk with your healthcare provider about any other over-the-counter or prescription drugs, as well as any supplements, herbal preparations, or other topical treatments that you may be using.

What Medications Are Similar?

Other topical antifugal drugs (drugs used on the skin for fungal infections) similar to Jublia include:

  • Ciclodan (ciclopirox)
  • Lotrimin (clotrimazole)
  • Nizoral (ketoconazole)
  • Monistat (miconazole)
  • Nystop (nystatin)
  • Lamisil (terbinafine)

Avoid using these drugs together unless your healthcare provider tells you to. Ask your pharmacist or a healthcare provider if you have any questions.

Frequently Asked Questions

  • What is Jublia used to treat?

    Jublia (efinaconazole) is used to treat fungal infections of the toenails. 

  • What are the common side effects of Jublia?

    Some common side effects include:

    • Dermatitis
    • Local irritation
    • Continued local pain or irritation
  • Where should I store Jublia?

    Store Jublia at room temperature, away from heat and flame.

  • What should I do if I miss a dose of Jublia?

    Apply the missed dose once you think of it. Skip the missed dose if it is too close to the next dose. Return to your regular dosing schedule. Do not use extra doses or double the amount.

  • Can I use nail polish while on Jublia?

    No. While taking this drug, avoid pedicures, nail polish or artificial ("fake") nails.

How Can I Stay Healthy While Using Jublia?

Toenail fungus does not go away overnight. You will have to be patient with this medicine. Use it as directed by your healthcare provider. Even if your toenail starts to look better, do not stop using it until your healthcare provider tells you to. Give your nails time to heal while using Jublia. And contact your healthcare provider if you have any concerns while using this drug.

Although pedicures can be relaxing, avoid pedicures, nail polish and artificial ("fake") nails while using this medicine. It's important to note that people can unfortunately also pick up fungal infections from manicures and pedicures at a salon. Ask your nail salon about their level of sanitation or check with your local health department if you have sanitation questions.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

3 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Food and Drug Administration. Jublia label.

  2. Efinaconazole. In: Drugs and Lactation Database (LactMed). National Library of Medicine (US); 2006.

  3. Gupta AK, Cooper EA. Long-term efficacy and safety of once-daily efinaconazole 10% topical solution (Jublia) for dermatophyte toenail onychomycosis: an interim analysis. Skin Therapy Lett. 2021;26(1):5-10.