Understanding Live Vaccines and Vaccine Shedding

Vaccines stimulate your body to produce immunity against an infection. Those known as live attenuated vaccines use a very weak form of a virus (occasionally, bacteria) to achieve this.

Using them means that a modified form of the threat, which the vaccine is meant to target, does enter the body. This is done to spur an immune system response, typically without causing illness.

Some people oppose live vaccine use because they think it can cause a virus to spread through a process called shedding. This article explains what that means and why there is little evidence to support this view.

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Live Vaccines and Viral Shedding

When a live vaccine is used to build immunity against a specific virus or other pathogen, the body's response is "virtually identical" to what you would see if you were naturally infected.

Live vaccines have saved lives. The process works against many threats, from chickenpox to cholera. But some people say that live vaccines can cause viral shedding.

Shedding is what happens when cells in a person's body release viral particles. For example, the virus can go into the air. This may increase the risk of spreading the infection to others.

The risk of viral shedding is a top reason why some people hold anti-vaccination views. They say that the use of vaccines, especially live ones, is unsafe.


Some vaccines are made by using a live but weaker form of the virus they are meant to target. This leads a healthy body's immune system to respond as intended. Some people oppose their use due to a risk of infection from viral shedding. This risk exists in theory but there is little evidence that it poses a real public health threat.

Live vs. Inactivated Vaccines

Live attenuated vaccines contain a weakened, mild form of a virus or bacteria. The vaccine is meant to stimulate an immune response in the form of antibodies, a type of protein that fights off infection.

The live vaccines stand in contrast to vaccines that use dead bacteria or viruses. These inactivated, or killed, vaccines are still recognized by the immune system as harmful. So they lead to the same antibody response.

Live vaccines are meant to simulate a natural infection. They are thought to be better in doing so than the killed vaccines. Usually, they provide lifelong protection with one or two doses. 

Most killed vaccines need to be given with more than one dose for a complete vaccination. People also tend to need boosters years later to keep the same level of immune protection. Your tetanus vaccine, which uses inactivated tetanus toxin, is one common example.

Live attenuated vaccines have a long history of being safe and effective. People who are immunocompromised often avoid live vaccines, though. This is due to a lower level of immune function that means they may get ill if one is given.

Live attenuated vaccines currently licensed in the United States include:

  • Adenovirus vaccine (Adenovirus type 4 and type 7, for military use only)
  • Chickenpox (varicella) vaccine (Varivax)
  • Cholera vaccine (Vaxchora)
  • Influenza nasal spray vaccine (FluMist)
  • Measles, mumps, and rubella (MMR) vaccines (M-M-R II, Priorix)
  • Measles, mump, rubella, and varicella (MMRV) vaccine (ProQuad)
  • Oral typhoid vaccine (Vivotif)
  • Rotavirus vaccines (Rotarix and RotaTeq)
  • Smallpox vaccine (ACAM2000)
  • Yellow fever vaccine (YF-Vax)

Two live attenuated vaccines commonly used in the past—a previous smallpox vaccine and the oral polio vaccine (OPV)—are no longer used in the U.S.

Bacille Calmette-Guérin (BCG) for tuberculosis is a live vaccine rarely used in the U.S. BCG and Vivotif are used to prevent a bacterial infection. All others are used to prevent viral infections. The BCG vaccine is also sometimes used as a treatment for bladder cancer.


Both live vaccines and inactivated, or killed, vaccines are effective in causing the body's immune system to respond to a target virus or bacteria. Live vaccines may be better at doing so because they are more like a natural infection. This makes the need for more than one dose, and boosters that come later, less likely.

Vaccine Shedding

When anti-vaxxers use the term vaccine shedding, they usually are referring to the risk of infection due to viral shedding. They say the shedding is caused by a vaccine that puts the virus itself into public circulation. Thus, the use of vaccines—especially live attenuated vaccines—would promote the spread of infection.

It is true that viral shedding is one way of spreading a virus. Certain vaccines can, in fact, lead to such shedding. However, there is little evidence that viral or bacterial vaccines can lead to the level of shedding that would cause a vaccinated person to transmit the infection to others.

Viral shedding in and of itself does not translate to a higher risk of viral spread. It is only when the level of shed viruses is high that transmission can occur.

To date, the only vaccine with the potential to raise the risk of infection is the oral polio vaccine (OPV). It is no longer used in the U.S.

Moreover, the viral shedding from OPV was concentrated in the stool (feces). This makes any contact with them, such as the fecal-oral route common with poor hygiene and hand washing, the primary way to cause such an infection.

There are few other documented cases of a virus that's spread because of a vaccine. These are some highlights and takeaways from medical research:

  • Killed vaccines can also cause viral shedding, but most studies find the level of shedding is not enough to cause an infection.
  • The chickenpox vaccine is not known to cause shedding unless it causes a rare vesicular rash in the body. The risk of transmission is thought to be very low. The CDC reports only five suspected cases out of 55 million doses of the varicella vaccine.
  • Like OPV, the rotavirus vaccine causes shedding in the stool. Viral spread can be avoided with better hygiene, such as good hand washing.
  • The rubella part of the MMR or MMRV vaccine may cause viral shedding into breast milk. This type of rubella spread to a breastfed baby is thought to be rare, if not unlikely.

Even so, viral shedding may pose risks to immunocompromised people when they have not been vaccinated against that specific virus. To this end, good hygiene may be the best defense. So is the routine practice of getting all the recommended vaccinations for adults and children.


Vaccine shedding is what anti-vaxxers are talking about when they say that a virus can be spread because a person got the vaccine for it. The theory is that this is due to the weak live virus in the vaccine. It's true that this is possible, but it's unlikely. A vaccine doesn't cause enough viral shedding to reach a threshold for spreading the virus.


Live vaccines don't cause disease. But they are made with weak forms of a virus or bacteria, and this means there is the risk that a person with a severely weakened immune system could get sick after getting one.

This is why organ transplant recipients typically avoid live vaccines. Among others, this also is true for people who have chemotherapy treatments and for those living with an advanced stage of HIV.

The decision to use or avoid a live vaccine in people with weakened immune systems is based largely on the degree of immune suppression. The benefits and risks must be weighed on a case-by-case basis.

For example, it is now recommended that children living with HIV receive the MMR, Varivax, and rotavirus vaccines. But this depends on their immune status, measured by the CD4 T-cell count.


Vaccines offer benefits that almost always outweigh the potential risks. With that said, there are several precautions to consider if you are scheduled to receive a live attenuated vaccine.

Among them:

  • More than one live attenuated vaccine can be given at the same time. If they aren't, you should wait at least four weeks before getting another live vaccine. This will limit any interference between them.
  • Children scheduled for a kidney or other solid organ transplant should have any live attenuated vaccines given at least four weeks before the surgery.
  • Children who take high-dose corticosteroid drugs like prednisone for 14 days or more may need to hold off on any live vaccines until their treatment is ended. Parents should advise their healthcare provider if a child is taking these drugs and a live vaccine is recommended.
  • Yellow fever vaccine should be avoided if you are breastfeeding. There have been rare cases of vaccine-associated encephalitis, or brain infection, in breastfed babies after a nursing parent was recently vaccinated.


A live attenuated vaccine contains a weak form of the live virus that it's meant to protect against. This is to spur the body to mount its own immune response in defense. Both live vaccines and inactivated, or killed, vaccines work this way, but the live vaccines may be better because they behave more like a natural infection.

Some people oppose the use of live vaccines. They base their anti-vax stance on vaccine shedding, or the belief that the vaccines will actually spread the virus rather than control it. This is because the weak, live virus enters the body through the vaccine. Anti-vaxxers say the virus can then be shed and passed to others.

This may be true in theory but not in practice. Live vaccines don't lead to shedding that causes high enough levels of the virus for it to spread, and therefore can't really cause other infections.

A Word From Verywell

When it comes to approved vaccines, the greater health risk likely comes from not getting your recommended vaccinations at all. The return of measles, once eliminated in the U.S., makes the risk clear. Avoiding a vaccine can place you or your child at greater risk of infection and lead to outbreaks of vaccine-preventable diseases.

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Frequently Asked Questions

  • Can you shed COVID-19 after you get the vaccine?

    The vaccine for COVID-19 is not a live virus, so it isn’t possible to shed the live coronavirus after getting the COVID shot. However, people who are vaccinated can still become infected with coronavirus. Once infected, it’s estimated that you would shed the virus for six to nine days after symptoms begin.

  • Can you be around an immunocompromised person if you’re vaccinated?

    You should avoid close contact with immunocompromised people if you receive the oral polio vaccine (which is no longer administered in the United States). It’s believed that other vaccines, even those with live viruses, pose little risk. However, if you develop a rash with blisters after receiving the chickenpox vaccine, you should talk to a healthcare provider and may need to isolate yourself temporarily.

  • What is vaccine shedding?

    Vaccine shedding is when your body releases the components of a live vaccine after you were given the shot or oral dose. In theory, this could make a person who was vaccinated able to infect others. This is a concern for the oral polio vaccine that was discontinued in the United States, but it’s not believed to be a problem for other types of vaccines.

25 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Centers for Disease Control and Prevention. National Center for Immunization and Respiratory Diseases. Principles of Vaccination.

  2. Vetter V, Denizer G, Friedland LR, Krishnan J, Shapiro M. Understanding modern-day vaccines: what you need to knowAnn Med. 2018;50(2):110-20. doi:10.1080/07853890.2017.1407035

  3. U.S. Department of Health and Human Services. Vaccine types.

  4. Centers for Disease Control and Prevention. Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine in adults aged 65 years and older - Advisory Committee on Immunization Practices (ACIP), 2012.

  5. Centers for Disease Control and Prevention. General recommendation on immunization.

  6. Centers for Disease Control and Prevention. Appendix B for the Pink Book-United States Vaccine Names.

  7. Plotkin S. History of vaccination. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12283-7. doi:10.1073/pnas.1400472111

  8. Centers for Disease Control and Prevention. BCG Vaccine.

  9. Fuge O, Vasdev N, Allchorne P, Green JS. Immunotherapy for bladder cancerRes Rep Urology. 2015 May;7:65–79. doi:10.2147/RRU.S63447

  10. Baker Institute of Public Policy. Scientific misconceptions and myths perpetuated in the 2017 Texas Legislative Session.

  11. Shearer WT, Fleisher TA, Buckley RH, et al. Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contactsJ Allergy Clin Immunol. 2014;133(4):961-6. doi:10.1016/j.jaci.2013.11.043

  12. Ferreyra-Reyes L, Cruz-Hervert LP, Troy SB, et al. Assessing the individual risk of fecal poliovirus shedding among vaccinated and non-vaccinated subjects following national health weeks in Mexico. PLoS One. 2017;12(10):e0185594. doi:10.1371/journal.pone.0185594

  13. Medical Advisory Committee of the Immune Deficiency Foundation, Shearer WT, Fleisher TA, et al. Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contactsJ Allergy Clin Immunol. 2014;133(4):961–966. doi:10.1016/j.jaci.2013.11.043

  14. Centers for Disease Control and Prevention. Chickenpox (varicella) vaccine safety.

  15. Centers for Disease Control and Prevention. Altered immunocompetence.

  16. National Library of Medicine. Measles-mumps-rubella-varicella vaccine. In: Drugs and Lactation Database (LactMed) [Internet].

  17. U.S. Department of Health and Human Services. Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children.

  18. Centers for Disease Control and Prevention. Vaccine safety: overview, history, and how the safety process works.

  19. Centers for Disease Control and Prevention. Timing and spacing of immunobiologics.

  20. Kim YJ, Kim SI. Vaccination strategies in patients with solid organ transplant: Evidences and future perspectives. Clin Exp Vaccine Res. 2016 Jul;5(2):125-31. doi:10.7774/cevr.2016.5.2.125

  21. Centers for Disease Control and Prevention. Travel and breastfeeding.

  22. Hotez P. America and Europe’s new normal: the return of vaccine-preventable diseasesPediatr Res. 2019;85:912-4. doi:10.1038/s41390-019-0354-3

  23. Takahashi K, Ishikane M, Ujiie M, et al. Duration of infectious virus shedding by sars-cov-2 omicron variant–infected vaccinees. Emerg Infect Dis. 2022;28(5). doi:10.3201/eid2805.220197

  24. Shearer WT, Fleisher TA, Buckley RH, et al. Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. Journal of Allergy and Clinical Immunology. 2014;133(4):961-966. doi:10.1016/j.jaci.2013.11.043

  25. Centers for Disease Control and Prevention. Myths and Facts about COVID-19 Vaccines.

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