What Are Short-Chain Fatty Acids?

The good bacteria in your gut help support your health in a variety of ways, including creating short-chain fatty acids. It’s believed short-chain fatty acids (SCFAs) play important roles in helping keep you healthy and preventing diseases. 

This article explores the potential health benefits of short-chain fatty acids.    

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Understanding Short-Chain Fatty Acids

Short-chain fatty acids (SCFAs) are a type of fatty acid with less than six carbon atoms. They are produced when the bacteria that live in your intestines ferment fiber. These bacteria and other microorganisms make up your gut microbiome, also called gut flora

In recent years, researchers have been exploring the effects of the gut microbiome on health. And they’ve found SCFAs play an important role in health and disease prevention. SCFAs are used by the cells in your intestines as energy, reduce inflammation, absorb minerals, aid metabolism, and other health benefits. 

The three main types of SCFAs produced are:

  • Acetate  
  • Propionate
  • Butyrate

Dietary Fiber and SCFAs

Dietary fiber is the part of food that bacteria ferment to create SCFAs. Fiber comes from plant-based foods, like fruits, vegetables, beans, and legumes. It gives plants its structure and binds the food together. 

Despite its many health benefits, fiber isn’t considered a nutrient because humans lack the enzymes to digest and absorb fiber. Instead, it promotes regularity in bowel movements by binding to nutrients and waste products created during digestion to pull them out of the body in the stool.

But the bacteria in the gut can break down and ferment some types of fiber. This helps promote the health of the “good” bacteria in the gut and produces SCFAs that the body can use.  

Soluble and Insoluble Fiber

Two main types make up the fiber in the human diet, called soluble and insoluble fiber. 

Soluble fiber dissolves in water and forms a gel-like consistency. It helps stool move through the digestive system easier and may improve blood sugar and cholesterol levels. 

Insoluble fiber doesn’t dissolve in water. It still attracts water and adds bulk to stool. Insoluble fiber promotes bowel regularity, may increase insulin sensitivity (response to insulin to take blood sugar into cells), and reduces the risk for colon diseases. 

Many plant foods contain a mix of soluble and insoluble fibers. A healthy diet should include both types of fiber.

Here are some of the foods high in soluble and insoluble fiber:

Soluble fiber:

  • Oats
  • Peas
  • Beans
  • Apples
  • Citrus fruits
  • Carrots
  • Barley

Insoluble fiber:

  • Whole wheat flour and products
  • Wheat bran
  • Beans
  • Nuts
  • Cauliflower
  • Green beans
  • Potatoes

Digestive Health Benefits of SCFAs

SCFAs provide numerous benefits for digestive health and other areas of the body. Here are some of the known health benefits of SCFAs: 

Improve Inflammatory Bowel Disease Symptoms

Inflammatory bowel disease (IBD) is a chronic condition that involves an overactive immune response in the gut and gut microbiome. The two forms of IBD are Crohn’s disease and ulcerative colitis

Research suggests that the SCFA butyrate may help reduce inflammation in the intestine, support healthy cells, and promote a healthy balance of gut bacteria.

It’s believed an imbalance of “good” and “bad” bacteria in the gut increases the risk of developing IBD. So, SCFAs may be important for preventing IBD and balancing the gut flora for people with IBD. 

Reduce Diarrhea

SCFAs may help prevent and ease digestive symptoms like diarrhea. A 2014 study found that a mixture of sodium butyrate and short-chain fatty acids reduced the risk of developing travelers’ diarrhea (diarrhea illness contracted from food or water during travel).

Lower Colon Cancer Risk

Changes in the gut microbiome are associated with an increased risk of developing colorectal cancer. Research suggests SCFAs may reduce the risk of colon cancer and improve survival rates by preventing the growth of cancer cells and promoting the death of cancer cells.

Help Control Blood Sugar and Diabetes

SCFAs may help regulate the hormones that impact blood sugar levels and diabetes risk. A study found that propionate helps support the health of beta cells in the pancreas, which are responsible for releasing the hormone insulin. 

Another 2019 study showed that SCFAs influence a hormone called glucagon-like peptide 1 (GLP-1), which helps regulate the secretion of the hormones insulin and glucagon. 

These effects may lower blood sugar levels, promote better blood sugar control, and lower the risk of developing type 2 diabetes. 

Support Healthy Weight Maintenance

The impacts of obesity-related health complications have led researchers to explore how to support people in maintaining a healthy weight. 

It’s believed the SCFA acetate may help people lose weight and support healthy weight maintenance. Acetate may be able to regulate hormones (like GLP-1), increase metabolism, and lower appetite. 

However, research is needed to understand these effects because many studies are animal models and the human research studies have mixed results. 

Protect Heart Health

Many research studies have linked a high fiber diet with a lower risk of cardiovascular diseases by lowering cholesterol, blood pressure, and inflammation. These effects are partially explained by the cholesterol-lowering effects of soluble fiber. It’s also believed the conversion of fiber into SCFAs helps support heart health. 

A research review discussed the potential cardiovascular benefits of SCFAs by reducing inflammation, cholesterol levels, and supporting weight loss. 

Ongoing Research About SCFAs

Researchers continue to explore the relationship between the SCFAs produced by gut bacteria and health. They’re still working to fully understand how it influences human health because most of the research studies show the influence of SCFAs on animal health. 

Early studies show similar health benefits in human studies. Still, more research and blind studies are needed to prove the effects. Researchers are continuing to explore the influence of SCFAs on gut, heart, metabolic, brain, and mental health. 

Recommended Fiber Intake

The current recommendations for daily fiber intake are around 30 to 35 grams for males and 25 to 32 grams for females. But most Americans only eat about 50% of the daily recommended amount of fiber. 

Fiber supplements are available. These help bulk up your stool, but it’s unclear if they provide the other health benefits of fiber. Aim for meeting your daily fiber needs from whole foods. 

Here is how many grams (g) are in one serving of some high fiber foods:

  • ½ cup of black beans: 6 grams
  • 1 medium apple: 2 grams
  • 1 packet of instant oatmeal: 4 grams
  • 1/2 avocado: 5 grams
  • 1 medium orange: 3 grams
  • 1 medium russet potato: 3 grams
  • 1 cup carrots: 4 grams
  • 1 cup green beans: 3 grams
  • 1 cup cauliflower: 3 grams


Short-chain fatty acids (SCFAs) are produced when gut bacteria ferment dietary fiber. The gut bacteria primarily produce three types of SCFAs, including acetate, butyrate, and propionate.

SCFAs may support health by reducing the risk of inflammatory bowel disease, colon cancer, reducing digestive symptoms, promoting healthy weight, improving blood sugar control, and other health benefits. A few high-fiber foods include beans, legumes, green beans, avocados, apples, oats, and citrus fruits. 

A Word From Verywell

Keeping your gut microbiome balanced appears to help support your overall health by lowering disease risk and producing helpful nutrients, like SCFAs. Eating plenty of high fiber foods provides fuel for the “good” gut bacteria to produce SCFAs and may support your overall health.

Frequently Asked Questions

  • What’s the difference between short-chain, medium-chain, and long-chain fatty acids?

    The main difference between short-chain, medium-chain, and long-chain fatty acids is simply the length of the molecules. Short-chain fatty acids have less than six carbons, medium-chain have six to 12 carbons, and long-chain have 13 to 21 carbons. 

    The different lengths change how the body absorbs and uses the nutrient.

  • Do short-chain fatty acids reduce inflammation?

    Research suggests that short-chain fatty acids may help reduce inflammation by preventing the pro-inflammatory bacteria from escaping through intestinal walls and interrupting other pathways that could cause inflammation.

  • Should I take supplements for short-chain fatty acids?

    You could take supplements for short-chain fatty acids and may see benefits to your health. But, the bacteria in the gut produce short-chain fatty acids by fermenting dietary fiber, so you can increase the amount of SCFAs in your body by eating more fiber.

11 Sources
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  1. Parada Venegas D, De la Fuente MK, Landskron G, et al. Short chain fatty acids (Scfas)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol. 2019;10:277. doi:10.3389/fimmu.2019.00277

  2. Barber TM, Kabisch S, Pfeiffer AFH, Weickert MO. The health benefits of dietary fibre. Nutrients. 2020;12(10):3209. doi:10.3390/nu12103209

  3. Gonçalves P, Araújo JR, Di Santo JP. A cross-talk between microbiota-derived short-chain fatty acids and the host mucosal immune system regulates intestinal homeostasis and inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(3):558-572. doi:10.1093/ibd/izx029.

  4. Krokowicz L, Kaczmarek BF, Krokowicz P, et al. Sodium butyrate and short chain fatty acids in prevention of travellers’ diarrhoea: a randomized prospective study. Travel Med Infect Dis. 2014;12(2):183-188. doi:10.1016/j.tmaid.2013.08.008.

  5. Gomes SD, Oliveira CS, Azevedo-Silva J, et al. The role of diet related short-chain fatty acids in colorectal cancer metabolism and survival: prevention and therapeutic implications. Curr Med Chem. 2020;27(24):4087-4108. doi:10.2174/0929867325666180530102050.

  6. Pingitore A, Chambers ES, Hill T, et al. The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro. Diabetes Obes Metab. 2017;19(2):257-265. doi:10.1111/dom.12811.

  7. Mandaliya DK, Seshadri S. Short chain fatty acids, pancreatic dysfunction and type 2 diabetes. Pancreatology. 2019;19(2):280-284. doi:10.1016/j.pan.2019.01.021.

  8. González Hernández MA, Canfora EE, Jocken JWE, Blaak EE. The short-chain fatty acid acetate in body weight control and insulin sensitivity. Nutrients. 2019;11(8):1943. doi:10.3390/nu11081943

  9. Chambers ES, Preston T, Frost G, Morrison DJ. Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health. Curr Nutr Rep. 2018;7(4):198-206. doi:10.1007/s13668-018-0248-8

  10. Zwartjes MSZ, Gerdes VEA, Nieuwdorp M. The role of gut microbiota and its produced metabolites in obesity, dyslipidemia, adipocyte dysfunction, and its interventions. Metabolites. 2021;11(8):531. doi:10.3390/metabo11080531

  11. Department of Agriculture. FoodData Central.