Viberzi (Eluxadoline) - Oral

What Is Viberzi?

Viberzi (eluxadoline) is a prescription medication used to treat irritable bowel syndrome (IBS) with diarrhea (diarrhea-predominant IBS, or IBS-D) in adults. It belongs to a class of drugs known as mu-opioid receptor agonists.

Viberzi works by stimulating or inhibiting various opioid receptors in the gut. It activates the mu-opioid receptors and kappa-opioid receptors and blocks the delta-opioid receptors. These receptors affect muscle movements, secretions, and sensations in the digestive tract. Viberzi's activity leads to reduced nerve sensitivity in the intestine and slows the movement of food through the colon.

Viberzi is classified as a schedule IV controlled substance, meaning it is regulated under federal law because of its potential for abuse and misuse.

Drug Facts

Generic Name: Eluxadoline

Brand Name(s): Viberzi

Drug Availability: Prescription

Administration Route: Oral

Therapeutic Classification: Antidiarrheal

Available Generically: No

Controlled Substance: Schedule IV

Active Ingredient: Eluxadoline

Dosage Form(s): Tablet

What Is Viberzi Used For?

The Food and Drug Administration (FDA) approved Viberzi to treat irritable bowel syndrome with diarrhea (IBS-D) in adults.

IBS-D is a subtype that causes frequent diarrhea with abdominal (stomach) pain. It is characterized as having more than a quarter of stools that are loose or watery and less than a quarter of stools that are hard or lump on days when you have at least one abnormal bowel movement.

Viberzi can provide relief to people with IBS-D who do not respond to other anti-diarrheal medications.

How to Take Viberzi

Viberzi is available as an oral tablet, which you will take by mouth. It's important to take the medication as prescribed, usually one tablet twice a day. Take each tablet with food.

Try to limit your alcohol intake while you're taking Viberzi. Drinking more than three alcoholic beverages per day while on this medication can put you at a higher risk of acute pancreatitis (inflammation of the pancreas).


Keep Viberzi tablets stored at room temperature (68 degrees to 77 degrees Fahrenheit).

What Are the Side Effects of Viberzi?

This is not a complete list of side effects and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your healthcare provider. You may report side effects to the FDA at or 1-800-FDA-1088.

Common Side Effects

The most common side effects with Viberzi include:

  • Constipation
  • Nausea
  • Abdominal pain
  • Upper respiratory infection

Talk to your healthcare provider if these side effects don’t go away or become more severe.

Severe Side Effects

Call your healthcare provider right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects can include:

  • Severe allergic reactions: Symptoms may include trouble breathing, hives, and swelling of the tongue, lips, mouth, or throat.
  • Pancreatitis (inflammation of the pancreas): Symptoms usually start with mild or severe pain in the upper abdomen. Other signs include bloating, tenderness, nausea, vomiting, and diarrhea.
  • Sphincter of Oddi spasm (a condition in which the sphincter muscle spasms, which can lead to the backup of bile or pancreatic enzymes in their ducts): Stop taking Viberzi if you think you're experiencing sphincter of Oddi spasm. Symptoms can include worsening abdominal pain that can radiate to the back or shoulder, with or without nausea and vomiting.
  • Severe constipation

Report Side Effects

Viberzi may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your healthcare provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much of Viberzi Should I Take?

Drug Content Provided and Reviewed by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For irritable bowel syndrome with diarrhea:
      • Adults—100 milligrams (mg) 2 times a day. Some patients may need 75 mg 2 times a day.
      • Children—Use and dose must be determined by your doctor.


No studies have been done on Viberzi use during pregnancy or breastfeeding. As such, you should consult your healthcare provider if you become or plan to become pregnant. They may weigh the risks versus benefits of stopping Viberzi with you.

Talk to your healthcare provider about any liver or kidney issues you have. Dosage changes may be necessary for people with mild or moderate liver impairments, although those with severe liver problems should not be prescribed Viberzi. You may also be prescribed a reduced dose if you have moderate or severe kidney impairment.

It is also essential to keep in mind that if you are 65 or older, you may be more likely to have side effects associated with this drug.

Missed Dose

If you miss your dose of Viberzi, skip the missed dose and take the next scheduled dose at the usual time. Do not take extra to make up for the missed dose. Doing so can increase your risk for side effects.

Overdose: What Happens If I Take Too Much Viberzi?

There have not been any reports of an overdose with Viberzi. To be safe, do not take more than prescribed by your healthcare provider.

What Happens If I Overdose on Viberzi?

If you think you or someone else may have overdosed on Viberzi, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Viberzi, call 911 immediately.


Drug Content Provided and Reviewed by IBM Micromedex®

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

If your symptoms and condition do not improve within a few days, or if they become worse, check with your doctor.

This medicine may increase your risk for sphincter of Oddi spasm. This is more likely to occur if you do not have a gallbladder. Call your doctor right away if you have new or worsening stomach pain or pain in the upper right abdominal or stomach that may move to your back or shoulders, with or without nausea or vomiting.

This medicine may increase your risk for pancreatitis (swelling of the pancreas). Check with your doctor right away if you have the following symptoms: bloating, chills, darkened urine, sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness, or yellow eyes or skin.

This medicine may cause severe constipation, which may require hospitalization. Check with your doctor right away if you have difficulty having a bowel movement.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema. These can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine.

If you have liver problems, do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Avoid drinking excessive alcohol while using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

What Are Reasons I Shouldn’t Take Viberzi?

There are a few reasons why your healthcare provider may not choose Viberzi as part of your treatment plan.


A person should not take Viberzi if they are allergic to the ingredients.


Since Viberzi is a controlled substance, there is a risk of dependence.


No studies have looked at Viberzi use during pregnancy. As such, it isn't certain if it will cause harm to the fetus. It is best to talk to your healthcare provider if you are pregnant or plan to become pregnant, so they can decide the best option for you.


It isn’t known if Viberzi passes into human milk. Talk with your healthcare provider if you are breastfeeding to discuss the best plan for you.

Older Adults

A person 65 years or older often processes drugs more slowly, which means they may be at higher risk of experiencing side effects. A lower dose or different schedule may be required.


Viberzi has not been approved for use in children.

Other Health Conditions

In certain individuals, the body may handle this drug differently. A person should inform their healthcare provider if they have:

What Other Medications Interact With Viberzi?

There are a few medications that can interact with Viberzi.

Medications that cause an increased risk of Viberzi side effects

When taken with these medications, more Viberzi can remain in the body, leading to an increased risk of side effects. A few examples of these medications include:

  • Gengraf, Neoral, Sandimmune (cyclosporine)
  • Lopid (gemfibrozil)
  • Antiretrovirals (e.g., ritonavir, lopinavir)
  • Rifadin (rifampin)
  • Promacta (eltrombopag)

Medications that cause an increased risk of constipation

These medications also cause constipation and should not be taken with Viberzi:

  • Opioids (e.g., hydrocodone)
  • Anticholinergics
  • Alosetron

Medications that have an increased risk of side effects when taken with Viberzi

Viberzi may cause an increased risk of side effects when taken with rosuvastatin. This can lead to an increased risk of myopathy or rhabdomyolysis.

This list does not include all drugs that can interact with Viberzi. Before using Viberzi, be sure to tell your healthcare provider about all the prescription medications, over-the-counter (OTC) medications, vitamins, supplements, or herbs you are taking. This will help you avoid potential interactions. If you have any questions about drug interactions, speak with your healthcare provider.

What Medications Are Similar?

Viberzi is often used to treat irritable bowel syndrome with diarrhea. There are a few other medications also used to treat irritable bowel syndrome with diarrhea, including:


Rifaximin is an antibiotic that works in the small intestine. It reduces abdominal pain, episodes of diarrhea, and bloating with irritable bowel syndrome with diarrhea. Xifaxan is available as an oral tablet. The most common side effects include headache, gas, nausea, and abdominal pain.


Alosetron HCL is a beta-blocker. It is often prescribed to treat irritable bowel syndrome with diarrhea in females (sex assigned at birth). Lotronex is available as an oral tablet. Common side effects include constipation, abdominal pain, or nausea. Lotronex does have a black box warning about ischemic colitis and severe complications of constipation.

Loperamide, an opioid agonist, is a commonly used OTC antidiarrheal medication to help reduce symptoms of acute diarrhea. However, clinical trials around its efficacy for pain relief in IBS have produced mixed results. It may not adequately control pain and bloating symptoms. The American College of Gastroenterology does not recommend using loperamide for overall symptom relief in people with IBS.

This list is a list of examples of medications used to treat irritable bowel syndrome with diarrhea. It is not a list of drugs recommended to take with Viberzi. Ask your healthcare provider if you have any questions.

Frequently Asked Questions

  • What is Viberzi used for?

    Viberzi works by affecting mu receptors, kappa receptors, and delta receptors in the gut. This leads to slower flood movement through the bowel and less nerve sensitivity in the intestine. Viberzi is often used to treat irritable bowel syndrome with diarrhea.

  • What are the side effects of Viberzi?

    The most common side effects are nausea, constipation, or abdominal pain. Viberzi also has the potential for serious side effects such as an allergic reaction, pancreatitis, or sphincter of Oddi spasm. If you are experiencing any serious side effects, call your healthcare provider right away. Call 911 if you are experiencing a medical emergency or life-threatening symptoms.

  • How do I safely stop taking Viberzi?

    Do not stop taking Viberzi without first speaking with your healthcare provider. They will be able to help come up with a plan for the safest way to stop taking the medication.

How Can I Stay Healthy While Taking Viberzi?

Viberzi is a safe and effective medication when used correctly. This drug is often used to treat irritable bowel syndrome with diarrhea in adults.

In addition to drug treatment, a low-FODMAP diet may also help relieve your symptoms. Similarly, you can also try the following diet changes:

  • Eat smaller meals
  • Avoid high-fat meals
  • Avoid fried foods
  • Keep a food diary
  • Identify and avoid trigger foods

While Viberzi does have the potential for serious side effects such as allergic reactions or pancreatitis, the most common side effects may be milder. Those tend to include abdominal pain, nausea, or constipation.

It is important to inform your healthcare provider of all your health conditions and any prescription medications, OTC medications, vitamins, supplements, or herbs you are taking. This way, your healthcare provider can decide what medication and dose are safe and work best for you.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

8 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  2. Lembo A, Lacy BE, Zuckerman MJ, et al. Eluxadoline for irritable bowel syndrome with diarrhea. N Engl J Med. 2016;374:242-253. doi:10.1056/NEJMoa1505180

  3. National Institute of Diabetes and Digestive and Kidney Diseases. Definition & facts for irritable bowel syndrome.

  4. Food and Drug Administration. Xifaxan label.

  5. Food and Drug Administration. Lotronex.

  6. Jones J, Lembo A, Heidelbaugh J, Kuritzky L, Lacy B. Management of irritable bowel syndrome with diarrhea: focus on eluxadoline. Gastroenterology. 2020. doi:10.1080/03007995.2021.1888705

  7. Ford A, Moayyedi P, Chey WD. American College of Gastroenterology monograph on management of irritable bowel syndrome. American Journal of Gastroenterology. 2018. doi:10.1038/s41395-018-0084-x

  8. Lacy B, Pimentel M, Brenner D, et al. ACG clinical guideline: management of irritable bowel syndrome. The American Journal of Gastroenterology. 2021. doi:10.14309/ajg.0000000000001036