Digestive Health Irritable Bowel Syndrome Digestive Enzymes: Types and Function A Necessary Part of Digestion By Barbara Bolen, PhD Barbara Bolen, PhD Twitter Barbara Bolen, PhD, is a licensed clinical psychologist and health coach. She has written multiple books focused on living with irritable bowel syndrome. Learn about our editorial process Updated on August 14, 2022 Learn more</a>." data-inline-tooltip="true"> Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Jay N. Yepuri, MD, MS Medically reviewed by Jay N. Yepuri, MD, MS Facebook LinkedIn Twitter Jay Yepuri, MD, MS, is a board-certified gastroenterologist and a practicing partner at Digestive Health Associates of Texas (DHAT). Learn about our Medical Expert Board Print Digestive enzymes are substances that help you digest your food. They are secreted (released) by the salivary glands and cells lining the stomach, pancreas, and small intestine. Digestive enzymes do this by splitting the large, complex molecules that make up proteins, carbohydrates, and fats into smaller ones. This allows the nutrients from these foods to be easily absorbed into your blood and carried through your body. Keep reading to learn about different types of digestive enzymes and how they work. Rost-9D / Getty Images What Are Digestive Enzymes? Digestive enzymes are released when we: Anticipate eatingSmell and taste foodGo through the digestive process Some foods require certain digestive enzymes to break down the specific nutrients they contain. A variety of health conditions, especially those that affect the pancreas, can lead to deficiencies in digestive enzymes. This is because the pancreas secretes several key enzymes. Often these deficiencies can be fixed by changing your diet. You can avoid certain foods or eat foods containing naturally occurring digestive enzymes. You can also take prescription or over-the-counter (OTC) enzyme supplements. Types of Digestive Enzymes Each of the many different digestive enzymes targets a specific nutrient and splits it up into a form that can eventually be absorbed. The most important digestive enzymes are: AmylaseMaltaseLactaseLipaseProteasesSucrase Amylase Amylase is important for digesting carbohydrates. It breaks down starches into sugars. Amylase is secreted by both the salivary glands and the pancreas. The measurement of amylase levels in the blood is sometimes used as an aid in diagnosing various pancreas or other digestive tract diseases. High levels of amylase in the blood may mean you have: A blocked or injured duct of the pancreas Pancreatic cancer Acute pancreatitis, which is a sudden inflammation of the pancreas Low levels of amylase may mean you have chronic pancreatitis (ongoing inflammation of the pancreas) or liver disease. Maltase The small intestine releases maltase, which is responsible for breaking down maltose (malt sugar) into glucose (simple sugar). The body uses glucose for energy. During digestion, starch is partially transformed into maltose by amylases. The maltase enzyme then changes maltose into glucose. This sugar is then either used immediately by the body or stored in the liver as glycogen for future use. Lactase Lactase (also called lactase-phlorizin hydrolase) is an enzyme that breaks down lactose, a sugar found in dairy products. It turns lactose into the simple sugars glucose and galactose. Lactase is produced by cells known as enterocytes that line the intestinal tract. Lactose that is not absorbed is fermented by bacteria in the gut. This can cause you to have gas and an upset stomach. Lipase Lipase is responsible for the breakdown of fats into fatty acids and glycerol (simple sugar alcohol). It's produced in small amounts by your mouth and stomach, and in larger amounts by your pancreas. Proteases Also called peptidases, proteolytic enzymes, or proteinases, these digestive enzymes break down proteins into amino acids. They also play a role in numerous body processes, including: Cell divisionBlood clottingImmune function Proteases are produced in the stomach and pancreas. The main ones are: Pepsin: Pepsin is secreted by the stomach to break down proteins into peptides, or smaller groupings of amino acids. Those amino acids are then either absorbed or broken down further in the small intestine. Trypsin: Trypsin forms when an enzyme secreted by the pancreas is activated by an enzyme in the small intestine. Trypsin then activates additional pancreatic enzymes, such as carboxypeptidase and chymotrypsin, to help break down peptides. Chymotrypsin: This enzyme breaks down peptides into free amino acids that can be absorbed by the intestinal wall. Carboxypeptidase A: Secreted by the pancreas, it splits peptides into individual amino acids. Carboxypeptidase B: Secreted by the pancreas, it breaks down basic amino acids. What Are Proteolytic Enzymes? Sucrase Sucrase is secreted by the small intestine, where it breaks down sucrose (the sugar in table sugar) into fructose and glucose. These are simpler sugars that the body can absorb. Sucrase is found along the intestinal villi. These are tiny hair-like structures that line the intestine and absorb nutrients into the bloodstream. Deficiencies There are a variety of health conditions that can interfere with the secretion of enough digestive enzymes to fully digest foods. Some are inherited genetic conditions while others develop over time. Lactose Intolerance Lactose intolerance occurs when you aren't able to digest lactose because of insufficient production of lactase by the small intestine. When you consume dairy products, you may experience: Bloating Diarrhea Abdominal pain Gas There are several forms of lactose intolerance. Congenital Lactase Deficiency Congenital lactase deficiency (also called congenital alactasia) is a rare inherited form of lactose intolerance. It happens when newborns are unable to break down lactose in breast milk or formula. They get severe diarrhea if they aren't given a lactose-free alternative. Congenital lactase deficiency is caused by mutations in the LCT gene that provides instructions for making the lactase enzyme. Lactase Non-Persistence Lactase non-persistence is a common type of lactose intolerance that some people develop as adults. It affects around 65% of people, and it's caused by decreased expression (activity) of the LCT gene. Symptoms typically begin 30 minutes to two hours after eating or drinking dairy. Most people with lactase non-persistence keep some level of lactase activity and can continue to include a small amount of lactose in their diets. This may be in the form of cheese or yogurt since both tend to be tolerated better than fresh milk. Secondary Lactose Intolerance Secondary lactose intolerance develops when lactase production is reduced because of diseases that can damage the small intestine. These diseases include celiac disease or Crohn's disease as well as other illnesses or injuries that affect the intestinal wall. Exocrine Pancreatic Insufficiency The pancreas produces the key digestive enzymes amylase, protease, and lipase. People with exocrine pancreatic insufficiency (EPI) have a deficiency of these enzymes. As a result, they are unable to digest food properly, especially fats. The health conditions that affect the pancreas and are associated with EPI are: Chronic pancreatitis: An inflammation of the pancreas that can permanently damage the organ over time Cystic fibrosis: An inherited genetic condition that causes severe damage to the lungs and digestive system, including the pancreas Pancreatic cancer Supplementation People who don't have sufficient amounts of digestive enzymes or who are looking to support healthy digestion should consider supplementing their diet with digestive enzymes. They can do this by eating healthy foods that contain naturally occurring digestive enzymes. But they can also take nutritional supplements under a healthcare provider's guidance. Digestive juices require hydration, so make sure that you drink water throughout the day. Foods A variety of foods, especially tropical fruits and fermented vegetables, are naturally high in digestive enzymes that might speed up the digestion of certain nutrients. It's best to eat them raw since heat can lessen or destroy these plant enzymes. Foods with Digestive Enzymes Food Enzymes Benefit Pineapple Proteases (bromelain) Helps digest proteins and has additional anti-inflammatory effects Papaya Proteases (papain) Helps digest proteins and is a popular meat tenderizer Kiwi Proteases (actinidain) In addition to its digestive enzymes, the fruit is high in fiber to support digestive tract function Mango Amylases Helps break down carbohydrates from starches into simple sugars and increases as the fruit ripens Banana Amylases, glucosidases Like amylases, glucosidases also break down complex carbohydrates Raw honey Amylases, Diastases, invertases, proteases The amylases and diastases help to break down starches, invertases break down sugars, and proteases break down protein Avocado Lipases Helps digest and metabolize fat Kefir Lipases, lactase, proteases The lactase in kefir helps to digest the fermented milk and may be tolerated by some people with lactose intolerance Sauerkraut, kimchi Lipases, proteases Fermented foods develop enzymes during the fermentation process as well as probiotics, or beneficial bacteria, to further support digestive health Miso Lactases, lipases, proteases, amylases This fermented soy paste contains a potent combination of enzymes that help break down lactose in dairy, fats, proteins, and carbohydrates Ginger Protease (zingibain) In addition to its enzymes that can help break down proteins, ginger may also help ease nausea Nutritional Supplements Digestive enzyme supplements can come in: PillsPowdersLiquids sourced from animals, plants, or microbes There are prescription supplements regulated by the FDA as well as over-the-counter supplements. Prescription enzyme supplements are recommended for conditions that affect the functioning of the pancreas, such as chronic pancreatitis or pancreatic cancer. Brands of prescription pancreatic enzyme supplements (pancrelipase) include Creon, Pancreaze, Zenpep, Ultresa, Viokace, and Pertzye. Over-the-counter enzyme supplements are not regulated by the FDA. There haven't been enough high-quality studies on them, so it's hard to know how effective they are. The following are some of the supplemental enzymes that don't require a prescription: Lactase supplements may help people who are lactose intolerant to digest dairy products and are available as tablets or drops. Bromelain is a powerful protease from the fruit or stem of pineapples that comes in capsule, tablet, or powder form and may help with the digestion of protein. Papain from papaya may help with digesting proteins, and the powder form can be used as a meat tenderizer. As with any supplement, check with your healthcare provider before taking an over-the-counter digestive enzyme to make sure it's safe for you. Summary Digestive enzymes are substances that help you digest your food. They're secreted by the salivary glands and cells lining the stomach, pancreas, and small intestine. Sometimes people have a digestive enzyme deficiency. These deficiencies are connected to various health conditions. Many of these health conditions are related to the pancreas. You can treat a digestive enzyme deficiency by changing your diet and/or taking a prescription or over-the-counter enzyme supplement. Before you decide to take an enzyme supplement, get your healthcare provider's advice. They can help you determine if it's safe for you. Frequently Asked Questions Who should take digestive enzyme supplements? If you have pancreatitis, pancreatic cancer, cystic fibrosis, or another disease of the pancreas, you may need to take prescription digestive enzymes. Those who are lactose intolerant can take OTC supplements. Researchers are exploring whether digestive enzymes may also help those with celiac disease. Learn More: Digestive Enzymes and Celiac Disease When should I take digestive enzymes? It depends on why you’re taking them. For example, prescription supplements for cystic fibrosis need to be taken at every meal and snack, but the dosage and timing may vary depending on what you’re eating or your age. Follow your healthcare provider's prescription or the OTC instructions. Learn More: An Overview of Cystic Fibrosis Diet and Supplements 11 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Peyrot des Gachons C, Breslin PA. Salivary amylase: digestion and metabolic syndrome. Curr Diab Rep. 2016;16(10):102. doi:10.1007/s11892-016-0794-7 Rompianesi G, Hann A, Komolafe O, Pereira SP, Davidson BR, Gurusamy KS. Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. Cochrane Database Syst Rev. 2017;4:CD012010. doi:10.1002/14651858.CD012010.pub2 Genetics Home Reference. Lactose intolerance. Mótyán JA, Tóth F, Tőzsér J. Research applications of proteolytic enzymes in molecular biology. Biomolecules. 2013;3(4):923-42. doi:10.3390/biom3040923 Genetics Home Reference. LCT gene. The National Pancreas Foundation. Exocrine pancreatic insufficiency (EPI). U.S. Food & Drug Administration. Updated questions and answers for healthcare professionals and the public: Use an approved pancreatic enzyme product (PEP). National Institute of Diabetes and Digestive and Kidney Diseases. Treatment for lactose intolerance. Pavan R, Jain S, Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi:10.1155/2012/976203 Gianluca I, Silvia P, Valentina G, Antonio G, Giovanni C. Digestive enzyme supplementation in gastrointestinal diseases. Current Drug Metabolism. 2016;17(2):187-193. doi:10.2174%2F138920021702160114150137 Cystic Fibrosis Foundation. Enzymes. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit Related Articles Lactase: Benefits, Side Effects, Dosage The 6 Best Digestive Enzymes of 2022, According to a GI Dietitian What to Know About Pancreatic Enzyme Replacement Therapy (PERT) What You Should Know About Lactose Intolerance Steatorrhea (Fatty Stool): Symptoms, Causes, and Treatment What Is Malabsorption Syndrome? What Is Lactose? Are Digestive Enzymes Just What You Need for Your Digestive Distress? 9 Foods Low in Lactose Do You Know the Difference Between Simple and Complex Carbs? 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